49ers’ Biggest Concern Before Rams Game? The EDGE Rusher Room

49ers’ Biggest Concern Before Rams Game? The EDGE Rusher Room

September 4, 2026 · 60 min · Season 7

About this episode

The episode discusses injury concerns for the 49ers ahead of their game against the Rams, focusing on key players and the EDGE rusher situation.

The San Francisco 49ers have some major injury questions heading into their upcoming game against the Los Angeles Rams. On this episode of 49ers Access, we break down the latest on Nick Bosa and George Kittle, including what their health could mean for the 49ers moving forward. We also examine a potentially serious problem developing along San Francisco's EDGE rusher group following Sam Okuayinonu's injury. With the 49ers already lacking depth at the position, how concerning is the situation heading into the season? We discuss the 49ers' defensive line, pass-rush depth, the importance of Nick Bosa, George Kittle's status and the biggest injury-related storylines surrounding San Francisco right now. Topics discussed: Nick Bosa injury update George Kittle injury update Sam Okuayinonu injury 49ers EDGE rusher depth 49ers pass rush 49ers defensive line San Francisco 49ers injury news 49ers roster concerns 49ers vs. Rams context Latest 49ers news and analysis Subscribe to 49ers Access for San Francisco 49ers news, injury updates, roster analysis, game reactions and NFL coverage. Subscribe and follow 49ers Access for the latest 49ers news, roster moves, rumors, injuries, reactions and…

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Organizations: San Francisco 49ers, Los Angeles Rams

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