Almost a virus – how AAV powers modern gene therapy
From Absolute Gene-ius by Jordan Ruggieri, Lisa Crawford
March 18, 2026 · 33 min · Season 4 · Episode 4
About this episode
The episode discusses the engineering and manufacturing of viral vectors for gene therapy with Dr. Dan Mitchell.
In this episode, the hosts sit down with Dr. Dan Mitchell of Matica Biotechnology to explore how viral vectors are engineered, analyzed, and manufactured for cell and gene therapy. The conversation spans CDMO workflows, AAV biology, and the critical role of qPCR and digital PCR in ensuring safety, quality, and performance.
People in this episode
Hosts: Jordan Ruggieri, Lisa Crawford
Guest: Dr. Dan Mitchell
Topics covered
- gene therapy
- viral vectors
- AAV biology
- CDMO workflows
- qPCR
- digital PCR
Keywords
- gene therapy
- AAV
- viral vectors
- qPCR
- digital PCR
- CDMO
- safety
- quality
Mentioned in this episode
Organizations: Matica Biotechnology, CDMO, qPCR, digital PCR
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