D-Dimer for Dissection and Evidence Update with Dr. Lauren Westafer

D-Dimer for Dissection and Evidence Update with Dr. Lauren Westafer

From ACEP Frontline - Emergency Medicine by ACEP Frontline

June 1, 2026 · 41 min

About this episode

Dr. Lauren Westafer discusses D-dimer testing and its implications for diagnosing aortic dissection and pulmonary embolism in emergency medicine.

From the halls of Holy Cross College and the Massachusetts ACEP Conference, ACEP Frontline talks with Dr. Lauren Westafer for a high-yield discussion on two of emergency medicine’s most impactful diagnoses: aortic dissection and pulmonary embolism. Dr. Westafer breaks down the evolving evidence behind D-dimer testing, including the 2026 practice-changing data and ACEP clinical policy updates supporting the use of the Aortic Dissection Detection Risk Score combined with D-dimer to help safely risk stratify select patients with suspected acute aortic syndromes. The conversation explores how this approach may reduce unnecessary advanced imaging while maintaining patient safety, along with practical pearls for identifying the patients who still warrant immediate CTA evaluation. The episode also reviews modern pulmonary embolism diagnosis and management, discussing risk stratification, and disposition decisions. It is a practical, evidence-based conversation focused on improving diagnostic accuracy, reducing over-testing, and delivering high-value emergency care. Mentioned in this episode: ACEP26

People in this episode

Guest: Dr. Lauren Westafer

Topics covered

  • aortic dissection
  • pulmonary embolism
  • D-dimer testing
  • risk stratification
  • emergency medicine
  • diagnostic accuracy

Keywords

  • D-dimer
  • aortic dissection
  • pulmonary embolism
  • risk stratification
  • ACEP clinical policy
  • advanced imaging
  • CTA evaluation

Mentioned in this episode

Organizations: ACEP

Places: Holy Cross College, Massachusetts ACEP Conference

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