Psilocybin's potential in treating methamphetamine use disorder with Jonathan Brett

Psilocybin's potential in treating methamphetamine use disorder with Jonathan Brett

From Addiction Audio by Addiction journal

March 6, 2026 · 20 min · Season 4 · Episode 8

About this episode

Dr Elle Wadsworth interviews Professor Jonathan Brett about the potential of psilocybin in treating methamphetamine use disorder.

In this episode, Dr Elle Wadsworth talks to Professor Jonathan Brett, a senior consultant at St. Vincent’s Hospital, Sydney, clinical director of the Psychiatry and Non-Prescription Drug and Alcohol Unit, and a clinical toxicologist with the New South Wales Poison’s Information Centre, Australia. The interview covers Jonathan’s research article looking at psilocybin-assisted psychotherapy for methamphetamine use disorder: A pilot open-label safety and feasibility study Psilocybin and what psilocybin-assisted psychotherapy looks like [01:20] Why look at methamphetamine use disorder? [04:38] Why is psilocybin promising for methamphetamine use disorder? [06:21] Explaining the single-arm open label pilot trial [09:35] The key findings of the study [10:54] The efficacy of psilocybin for methamphetamine use disorder treatment [12:12] The implications of the findings for policy and practice [14:50] The increased interest in psychedelics and a note of caution [17:03] About Elle Wadsworth: Elle is an academic fellow with the Society for the Study of Addiction. She is based at the University of Bath with the Addiction and Mental Health Group and her research interests include drug policy…

People in this episode

Host: Dr Elle Wadsworth

Guest: Professor Jonathan Brett

Topics covered

  • psilocybin
  • methamphetamine use disorder
  • psychotherapy
  • addiction medicine
  • clinical research
  • psychedelics

Keywords

  • psilocybin
  • methamphetamine
  • addiction treatment
  • clinical trial
  • psychotherapy
  • safety study
  • feasibility study
  • psychedelics
  • drug policy

Mentioned in this episode

Organizations: St. Vincent’s Hospital, New South Wales Poison’s Information Centre, Society for the Study of Addiction

Books & works: Psilocybin-assisted psychotherapy for methamphetamine use disorder: A pilot open-label safety and feasibility study

Places: Sydney, Australia

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