About this episode

The episode discusses the economics of clinical trials and the potential impact of AI on improving trial outcomes.

Clinical trials are a massive industry with brutal economics, long timelines, and failure rates that would be unacceptable in almost any other sector. In this episode, Dr Andree Bates is joined by Dr Joseph Geraci of NetraMark to break down why trials fail so often, how patient heterogeneity drives cost and uncertainty, and where AI can realistically shift the economics. Joseph shares his unusual path from mathematics and mathematical physics into oncology and medical science, including a decision to move into hospital research rather than follow a more traditional academic route. That shift shaped his focus: not just discovering more molecules, but understanding why the same drug can work brilliantly for some patients and fail for others. A central theme is that clinical trials are not “one disease, one patient type”. In many areas, disease definitions are too broad for trial design, making trials feel like trying to hit multiple dartboards with one dart. Joseph explains how NetraMark’s approach aims to identify meaningful subpopulations inside small datasets, finding the “pocket” where a drug’s true advantage shows up, without discarding patients as outliers. The conversation…

People in this episode

Host: Dr Andree Bates

Guest: Dr Joseph Geraci

Topics covered

• clinical trials
• AI in healthcare
• patient heterogeneity
• drug efficacy
• trial economics

Mentioned in this episode

Organizations: NetraMark

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