When Agents Negotiate With Agents with Microsoft Research's Saleema Amershi

When Agents Negotiate With Agents with Microsoft Research's Saleema Amershi

February 28, 2026 · 46 min · Episode 116

About this episode

Saleema Amershi discusses the challenges and implications of AI agents negotiating and collaborating with each other.

This episode is sponsored by Airia. Get started today at ⁠⁠⁠⁠⁠⁠⁠⁠⁠airia.com⁠⁠⁠⁠⁠⁠⁠⁠⁠. Saleema Amershi is a Partner Research Manager at Microsoft Research AI Frontiers, where she leads the teams behind AutoGen and Magentic-One. She joins the AI Inside podcast to discuss what happens when AI agents stop working in isolation and start collaborating, transacting, and negotiating with each other at scale. We cover the challenges of multi-agent orchestration, why current frontier models show a dangerous first-proposal bias that favors speed over quality, and how her team built the Magentic Marketplace to simulate agent-to-agent commerce. We also dig into agent manipulation, the tension between walled gardens and open ecosystems, and what duty of care means when an AI is acting on your behalf. Note: Time codes subject to change depending on dynamic ad insertion by the distributor. Chapters: 0:00 - Podcast Start 01:46 - Introduce Saleema Amershi 0:02:04 - Talk about the challenges surrounding the orchestration of these agents together. And what limits this collaboration today, is it a technical limitation or something deeper? 0:05:10 - OpenClaw perspectives 0:06:42 - From your research…

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