When psychiatric illness isn't just psychiatric--  The immune system, PANS, and psychiatric mimicry

When psychiatric illness isn't just psychiatric-- The immune system, PANS, and psychiatric mimicry

December 26, 2025 · 1h 21m · Season 7 · Episode 8

About this episode

This episode discusses the intersection of psychiatric illness and autoimmune responses, highlighting conditions like PANDAS and PANS.

There is a growing awareness in psychiatry that not all psychiatric illness is psychiatric— some percentage of what presents in psychiatric settings is actually triggered by autoimmune responses to various pathogens and insults. In the late '90s a syndrome called PANDAS (pediatric autoimmune neuropsychiatric disorders associated with strep) came on the scene with cases of sudden onset OCD and tics that appeared in conjunction with strep infections. The theory behind PANDAS was that part...

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