About this episode

The episode discusses the use of PARP inhibitor combinations in advanced prostate cancer, focusing on clinical trials and personalized treatment strategies.

With multiple clinical trials evaluating PARP inhibitor combinations, how do clinicians determine the best approach for advanced prostate cancer? In this episode of BackTable Urology, Dr. Alan Tan is joined by Dr. Rana McKay and Dr. Emmanuel Antonarakis to discuss how evolving evidence, patient selection, timing, toxicity, and genetic testing are shaping the use of PARP inhibitor combinations in clinical practice. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Pfizer. --- Timestamps 00:00 - Introduction02:51 - PARPi Basics14:12 - Major Study Differences19:00 - Timing and Selection of PARPi Combinations26:39 - Case: Somatic BRCA2 loss and mHSPC35:51 - Case Continued: BRCA2 Reversion39:57 - BRCAAway Study42:59 - Takeaways from the 2026 APCCC --- More about this episode The conversation reviews lessons learned from major clinical trials, including PROpel, MAGNITUDE, TALAPRO-2, and AMPLITUDE, and addresses how these studies inform real-world treatment choices. The doctors dig into case examples, such as BRCA2 loss and reversion, and highlight practical strategies for using germline and somatic testing to personalize…

People in this episode

Host: Dr. Alan Tan

Guests: Dr. Rana McKay, Dr. Emmanuel Antonarakis

Topics covered

• PARP inhibitors
• prostate cancer
• clinical trials
• patient selection
• genetic testing
• precision medicine

Keywords

• PARP inhibitors
• prostate cancer
• clinical trials
• BRCA2
• genetic testing
• precision medicine
• toxicity
• patient selection

Sponsors

Pfizer

Mentioned in this episode

Books & works: PROpel, MAGNITUDE, TALAPRO-2, AMPLITUDE, BRCAAway Study

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