About this episode

Joshua Leisk discusses his systems biology model for chronic illnesses, focusing on interconnected factors that contribute to disease persistence and recovery.

🎧 Episode Summary Joshua Leisk continues the discussion of his systems biology model for ME/CFS, Long COVID, and related chronic illnesses, focusing on how lymphatic dysfunction, sympathetic nervous system dominance, metabolic impairment, and chronic stress responses may contribute to the persistence of complex chronic conditions. He explores the relationships between cortisol regulation, trauma, autonomic imbalance, energy metabolism, and the body's ability to maintain resilience and recovery. The conversation examines how biofilms, chronic infections, viral reactivation, hypoxia, oxidative stress, and immune system blind spots may interact to drive ongoing symptoms and disease progression. Joshua discusses the potential roles of microbial adaptation, mitochondrial dysfunction, connective tissue disorders, circulatory challenges, and inflammatory signaling in creating self-perpetuating cycles of illness. Joshua shares his perspective that meaningful recovery requires addressing the interconnected factors underlying chronic illness, including metabolism, nutrient status, autonomic regulation, lymphatic flow, structural integrity, and immune function. He suggests that restoring…

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