Effects of ZNF467 on HSPC fitness and Promotion of Follicular Lymphoma via DC-SIGN

About this episode

This episode features discussions on the impact of ZNF467 on stem cell fitness and the role of DC-SIGN in follicular lymphoma.

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Francesco Forconi and Bin Guo on their latest articles published in Blood. Dr. Guo shares insights from " Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming ". The findings establish biomechanical regulation as an important determinant of stem cell identity and reveal new strategies for engineering stem cells with enhanced regenerative capacity. Then, Dr. Forconi discusses " DC-SIGN binding to the surface immunoglobulin oligomannose-type glycans promotes follicular lymphoma cell adhesion and survival ". Persistent, low-level BCR engagement by DC-SIGN enables FL tissue retention and survival while avoiding the deleterious proapoptotic consequences of stronger, conventional antigen-driven BCR signaling. These findings help explain how FL cells exploit their microenvironmental niche.

People in this episode

Host: Dr. James Griffin

Guests: Dr. Francesco Forconi, Dr. Bin Guo

Topics covered

• hematopoietic stem cells
• follicular lymphoma
• biomechanical regulation
• cell adhesion
• microenvironmental niche

Keywords

• ZNF467
• HSPC fitness
• follicular lymphoma
• DC-SIGN
• stem cell engraftment
• ICAM1
• BCR signaling

Mentioned in this episode

Organizations: Blood

Books & works: Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming, DC-SIGN binding to the surface immunoglobulin oligomannose-type glycans promotes follicular lymphoma cell adhesion and survival

More episodes of Blood Podcast

• Future Directions in Relapsed and Refractory Large B-cell Lymphoma · June 11, 2026 · 25 min
• Review Series on Clonal Tracking in Hematopoiesis · June 4, 2026 · 30 min
• New Approaches: Marstacimab Therapy and HLH Biomarkers · May 28, 2026 · 18 min
• Review Series on Hemophagocytic Lymphohistiocytosis (HLH) · May 21, 2026 · 16 min
• IBD augmentation of CHIP and Platelet mTOR's impact on Cerebral Malaria · May 14, 2026 · 21 min
• Long-term efficacy and safety of betibeglogene autotemcel for β-thalassemia · May 7, 2026 · 13 min