#136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation

About this episode

The episode discusses the challenges and developments related to Group A Streptococcal infections, featuring expert insights and practical applications for healthcare professionals.

Group A Streptococcal infections remain a global challenge, spanning common conditions like pharyngitis to severe invasive disease. Dr. Shiranee Sriskandan, Dr. Josh Osowicki, and Dr. Tom Parks join host Dr. Erin McCreary to explore the evolving landscape of Group A Strep. From unpacking vaccine development challenges and the ongoing burden of rheumatic fever, to rethinking durations of therapy for strep throat and the role of adjunctive treatments, we have you covered! Join us as we break down key controversies, share expert insights, and highlight practical pearls you can apply in your own practice. References: 1. https://www.lancefieldsociety.org/ 2. Osowicki J, Lamagni TL. Invasive Group A Streptococcal Disease in the US. JAMA . 2025;333(17):1493-1494. doi:10.1001/jama.2025.3257 3. Davis K, Abo YN, Steer AC, Osowicki J. Chains of misery: surging invasive group A streptococcal disease. Curr Opin Infect Dis. 2024;37(6):485-493. doi:10.1097/QCO.0000000000001064 4. Osowicki J, Azzopardi KI, Fabri L, et al. A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study. Lancet Microbe. 2021;2(7):e291-e299…

People in this episode

Host: Dr. Erin McCreary

Guests: Dr. Shiranee Sriskandan, Dr. Josh Osowicki, Dr. Tom Parks

Topics covered

• Group A Streptococcus
• vaccine development
• rheumatic fever
• strep throat treatment
• adjunctive treatments
• infectious diseases

Keywords

• Group A Streptococcus
• pharyngitis
• invasive disease
• vaccine challenges
• rheumatic fever
• treatment duration
• adjunctive therapies

Mentioned in this episode

Organizations: Society of Infectious Diseases Pharmacists

Books & works: JAMA, Curr Opin Infect Dis, Lancet Microbe

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