From Partnered ASO Therapies To A Wholly-Owned Pipeline With Ionis's Brett Monia, Ph.D.

From Partnered ASO Therapies To A Wholly-Owned Pipeline With Ionis's Brett Monia, Ph.D.

May 4, 2026 · 56 min · Episode 304

About this episode

Brett Monia, Ph.D., discusses the evolution of antisense oligonucleotides and Ionis Pharmaceuticals' strategic shift to a wholly-owned pipeline.

We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech, Brett Monia, Ph.D., CEO at Ionis Pharmaceuticals, talks about how antisense oligonucleotides (ASO) graduated from a late-1980s lab concept to real RNA-targeting medicines, and why Ionis stuck with a difficult modality despite multiple setbacks. Brett describes the company's shift from a partner-first model to building a wholly-owned pipeline, commercial function, and an expanded manufact...

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Host: Ben Comer

Guest: Brett Monia, Ph.D.

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Organizations: Ionis Pharmaceuticals

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