450. Journal Club: The I-CLASS Registry with Dr. Theofanie Mela and Dr. Pugazhendhi Vijayraman

About this episode

The episode discusses the results of the I-CLASS Registry, comparing clinical outcomes of biventricular pacing and left bundle branch area pacing in patients undergoing cardiac resynchronization therapy.

Join CardioNerds EP Council Chair Dr. Naima Maqsood and Episode Lead Dr. Sukriti Banthiya as they discuss the results of the International Collaborative LBBAP Study (I-CLAS) with expert faculty Dr. Theofanie Mela and Dr. Pugazhendhi Vijayraman . Audio editing by CardioNerds academy intern, Grace Qiu. The International Collaborative LBBAP Study (I-CLAS) evaluated clinical outcomes between biventricular pacing (BVP) and left bundle branch area pacing (LBBAP) in patients with left ventricular ejection fraction (LVEF) ≤50% undergoing cardiac resynchronization therapy. Between January 2018 and June 2023, 2,579 patients were enrolled across 18 centers. The primary composite outcome was defined as all-cause mortality or heart failure hospitalization. LBBAP demonstrated a shorter paced QRS duration and was associated with a lower risk of primary composite outcome and heart failure hospitalization. No significant difference was observed in all-cause mortality. Additionally, procedural complications were lower with LBBAP. This episode was planned in collaboration with Heart Rhythm TV with mentorship from Dr. Daniel Alyesh and Dr. Mehak Dhande.   Enjoy this Circulation 2022 Paths to…

People in this episode

Hosts: Dr. Naima Maqsood, Dr. Sukriti Banthiya

Guests: Dr. Theofanie Mela, Dr. Pugazhendhi Vijayraman

Topics covered

• cardiology
• heart failure
• cardiac resynchronization therapy
• biventricular pacing
• left bundle branch area pacing

Keywords

• I-CLASS Registry
• biventricular pacing
• left bundle branch area pacing
• heart failure hospitalization
• cardiac resynchronization therapy

Mentioned in this episode

Organizations: CardioNerds, Heart Rhythm TV, US Cardiology Review

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