About this episode

The episode discusses respiratory acidosis, its physiological effects, and related research findings.

References Biff Palmer! Respiratory Acidosis and Respiratory Alkalosis: Core Curriculum 2023 Josh what is sensed- pCO2 or pH and some exploration suggests that it is not settled! Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes - PMC and this one with catchy title: Out of thin air: Sensory detection of oxygen and carbon dioxide - PMC If anna does VOG on Haldane- we’ll need references  The Response of Extracellular Hydrogen Ion Concentration to Graded Degrees of Chronic Hypercapnia: The Physiologic Limits of the Defense of pH - PMC (this is the correct reference for figure 20-3 reference).  JC shared some info from Dr. Adrogue  Josh mentioned potential differences between people with respect to oxygen sensors and this study of sherpas: [Association of polymorphisms of 1772 (C-->T) and 1790 (G-->A) in HIF1A gene with hypoxia adaptation in high altitude in Sherpas] and this excellent review: Sensing hypoxia: physiology, genetics and epigenetics - PMC VOG from Amy on renal failure with respiratory acidosis https://pubmed.ncbi.nlm.nih.gov/38936337/ Joel and Roger mention these two perspectives on alkali therapy for…

Topics covered

• Respiratory Acidosis
• Physiological Effects
• Oxygen Sensors
• Hypercapnia
• Alkali Therapy
• Genetics and Epigenetics

Keywords

• Respiratory Acidosis
• pCO2
• pH
• Hypercapnia
• Oxygen Detection
• Alkali Therapy
• HIF1A
• Sherpas
• Renal Failure

Mentioned in this episode

Organizations: PMC, American Journal of Kidney Diseases, NEJM, HIF1A

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