About this episode

The episode discusses disorders of osmolality, focusing on hyponatremia and related conditions.

References This is the famous Edelman equation from JCI in 1958 by Isodore Edelman! Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water (not to be confused by Isildur House of Isildur - Tolkien Gateway Joel mentioned his slide deck on Edelman: https://pbfluids.com/wp-content/uploads/2023/04/QN_III-The-Edelman-Equation-full-lecture-from-2020-07-30.pdf This is an excellent review (with great figures) on Osmotic homeostasis by Danziger and Zeidel in CJASN  Joel and JC mentioned the work from Joseph Verbalis on hyponatremia- this is an excellent review that includes population data from NHANES plus striking images of the osteopenic bones in hyponatremic rats! Check this out! Hyponatremia‐induced osteoporosis - Verbalis - 2010 - Journal of Bone and Mineral Research - Wiley Online Library Joel and JC mentioned “reference 2” from the chapter by Kleeman and others on diuretic induced hyponatremia which invoked hypokalemia as an important player: Diuretic-Induced Hyponatremia | Annals of Internal Medicine We couldn't help flirting with diarrhea a little Secretory diarrhoea: mechanisms and…

Topics covered

• Osmolality disorders
• Hyponatremia
• Osmotic homeostasis
• Diuretic-induced hyponatremia
• Salt cravings
• Fluid balance

Keywords

• Edelman equation
• serum sodium concentration
• osmolarity
• total body water
• diuretic-induced hyponatremia
• Gitelman syndrome
• osteopenic bones
• salt cravings

Mentioned in this episode

Organizations: JCI, CJASN, Journal of Bone and Mineral Research, Annals of Internal Medicine, PMC

Books & works: Diuretic-Induced Hyponatremia, Secretory diarrhoea: mechanisms and emerging therapies, Gitelman syndrome in a South African family presenting with hypokalaemia and unusual food cravings, Saltiest Sodium. Dumbest Dude Volume Depletion versus Dehydration

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