Click chemistry marks 25 years & covalent bonding in the actinides | The chemical breakdown podcast

Click chemistry marks 25 years & covalent bonding in the actinides | The chemical breakdown podcast

June 10, 2026 · 28 min

About this episode

The episode discusses the evolution of click chemistry over 25 years and the bonding behavior of actinides.

This week, we look back at how far click chemistry has come in the last 25 years and discuss the strange bonding behaviour of some of the largest elements on the periodic table with Mason Wakley and Frances Briggs. It started as a review paper in 2001 that has since been cited almost 20,000 times, becoming one of the most influential chemistry papers ever written. Click chemistry has revolutionised the way we build molecules. But what defines a click reaction, and what does the future hold? And, new research has revealed experimental evidence of how covalent bonding affects the 5f orbital in early actinides. We discuss the challenges of studying these elements.

People in this episode

Guests: Mason Wakley, Frances Briggs

Topics covered

Keywords

Mentioned in this episode

Books & works: click chemistry

More episodes of Chemistry in its element

Explore listener stats, chart rankings, contacts and more on the Chemistry in its element podcast page.