Safety in oHCM Therapy: How and When to Transition Treatment?

About this episode

This episode discusses the management and treatment transitions in obstructive hypertrophic cardiomyopathy, focusing on safety and individualized therapy.

Faculty: Anjali Owens, MD This activity examines the evolving management of obstructive hypertrophic cardiomyopathy (oHCM), from persistent unmet needs to precision-based therapy with cardiac myosin inhibitors. Faculty review ongoing symptom burden and functional limitations despite guideline-directed first-line therapy with beta-blockers and analyze mechanistic, pharmacokinetic, and pharmacodynamic differences among available agents, including their effects on peak VO₂, left ventricular outflow tract gradients, and patient-reported outcomes. Through expert discussion and case-based application, the activity highlights practical considerations for treatment selection, individualized dosing and titration, safety monitoring, and treatment transitions to support evidence-based strategies that optimize hemodynamics and improve quality of life in patients with oHCM.

People in this episode

Guest: Anjali Owens, MD

Topics covered

• obstructive hypertrophic cardiomyopathy
• treatment transition
• precision-based therapy
• cardiac myosin inhibitors
• safety monitoring
• individualized dosing

Keywords

• oHCM
• treatment selection
• hemodynamics
• quality of life
• symptom burden
• functional limitations
• pharmacokinetics
• pharmacodynamics

Mentioned in this episode

Organizations: ReachMD, cardiac myosin inhibitors, beta-blockers, obstructive hypertrophic cardiomyopathy

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