Is This Right for Me? NAD+: Why the "Longevity Molecule" Story Just Got Complicated

About this episode

This episode explores the complexities surrounding NAD+, the 'longevity molecule', and its implications for health and aging.

NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on. In this episode, Jeff breaks down what NAD+ actually is, what the human trials really show, and why the gap between a $40 oral supplement and a $1,200 IV drip matters more than the marketing admits. You’ll learn about: What NAD+ does in the body and why it got tied to aging The new research questioning whether NAD+ truly declines with age Oral NR and NMN versus IV infusions, and what the evidence supports The risks rarely mentioned, including the cancer question Why the saline, B vitamins, and forced rest may explain how good people feel This episode is for anyone weighing NAD+, longevity supplements, or an IV drip, and who wants to tell real science from wellness hype first. This episode was made possible by: LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot…

People in this episode

Host: Jeff Krasno

Topics covered

• NAD+
• longevity
• supplements
• human trials
• aging
• health risks

Keywords

• NAD+
• longevity supplements
• IV drip
• oral NR
• NMN
• human trials
• aging
• health risks

Sponsors

LMNT, Stemregen, Vivobarefoot, Stripes, Sunlighten

More episodes of Commune with Jeff Krasno

• Menopause, Hormones, and Spiritual Healing with Gabby Bernstein · June 11, 2026 · 44 min
• Is This Right for Me? Cold Plunges: Mood, Metabolism & the Wim Hof Method, Decoded · June 9, 2026 · 54 min
• The Menopause Gut: How Hormones Shape Your Microbiome with Cynthia Thurlow · June 4, 2026 · 1h 7m
• Waking Up with Sam Harris: Mindfulness, Non-Duality, and the Illusion of the Self · May 28, 2026 · 55 min
• Is This Right for Me? Liver Detoxes: Milk Thistle, Juice Cleanses, and the Real Evidence · May 26, 2026 · 29 min
• Making Sense of the Chaos with Sam Harris: Politics, Tribalism, and the Outrage Machine · May 21, 2026 · 51 min