Episode #224 Cognitive Decline is No Longer Inevitable with James Maskell and Dr. Kristine Burke

Episode #224 Cognitive Decline is No Longer Inevitable with James Maskell and Dr. Kristine Burke

May 5, 2026 · 34 min

About this episode

The episode discusses the hidden drivers of cognitive decline and the potential of precision medicine to prevent Alzheimer's disease.

Without intervention, in 2050, everyone in the US population will either have Alzheimer’s disease or be caring for someone with Alzheimer’s disease. That’s the state of where we’re at with cognitive decline. Right now, if you reach the age of 85, your chances of developing cognitive decline are 1 in 2. That’s right, 50%. But, BUT, new research is helping us understand the hidden drivers of cognitive decline and creating hope at the same time. Because now that we understand the origin of risk for an individual, we can prescribe specific interventions to circumvent that risk and prevent the disease altogether. This is the amazing work of James Maskell and Dr. Kristine Burke, my guests on the show today. Dr. Burke is Co-PI of the EVANTHEA Study, a clinical trial designed to look at the impact of a precision medicine approach to Alzheimer’s disease. The initial results are astounding – with intervention, 91% of participants saw improvement in cognitive function. That’s better than any drug, lifestyle medicine, or treatment protocol we have to date by a long shot. These two join me today to talk about what those hidden drivers are, how precision medicine can help, who’s going to…

People in this episode

Host: Zeev Neuwirth

Guests: James Maskell, Dr. Kristine Burke

Topics covered

Keywords

Mentioned in this episode

Organizations: EVANTHEA Study, True Health Center for Precision Medicine

More episodes of Creating a New Healthcare

Explore listener stats, chart rankings, contacts and more on the Creating a New Healthcare podcast page.