Chemically Imbalanced? An Interview with Psychiatrist Joanna Moncrieff

Chemically Imbalanced? An Interview with Psychiatrist Joanna Moncrieff

December 5, 2025 · 41 min · Season 6 · Episode 12

About this episode

The episode features an interview with psychiatrist Joanna Moncrieff discussing her research on psychiatric drugs and the chemical imbalance theory.

To donate to my PayPal (thank you): https://paypal.me/danieru22?country.x=US&locale.x=en_US Joanna Moncrieff is a psychiatrist, researcher, and author based at University College London. Her work examines the foundations of modern psychiatric practice, especially our assumptions about how psychiatric drugs work and why we use them. For decades, the dominant idea has been the disease-centred model: the view that mental disorders are caused by underlying chemical abnormalities, and medications correct those abnormalities. Moncrieff's research challenges this perspective. Instead, she proposes the drug-centred model, which understands psychiatric drugs as substances that create altered mental and emotional states. She views these as states that may sometimes suppress or shift distress, but do not “fix” an underlying chemical imbalance. She is the author of several books, including The Myth of the Chemical Cure, The Bitterest Pills, A Straight Talking Introduction to Psychiatric Drugs, and her most recent, Chemically Imbalanced: The Making and Unmaking of the Serotonin Myth. You can find this here…

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