The Estrogen Effect Nobody Talks About | Kiran Krishnan

About this episode

Dr. Kara Fitzgerald and Kiran Krishnan discuss the impact of estrogen decline on cardiovascular health and the role of the gut microbiome in aging.

Cardiovascular health and longevity are deeply influenced by aging, perimenopause, and systemic changes that extend far beyond cholesterol markers alone. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Kiran Krishnan to explore the biology of vascular aging, endothelial dysfunction, and metabolic changes that emerge in midlife and beyond. As estrogen declines during perimenopause, patients often experience shifts in lipid metabolism, weight regulation, and overall metabolic resilience—driving increased cardiovascular risk. This conversation dives into the critical role of the endothelial glycocalyx, nitric oxide signaling, and the gut microbiome in maintaining vascular integrity and systemic health. Dr. Fitzgerald and Kiran connect the dots between gut health, cardiovascular disease, joint degeneration, and systemic inflammation, offering a systems biology approach that is highly relevant for functional medicine practitioners. You’ll also hear how targeted interventions—specifically Arterosil, Vascanox, and Cartigenix—can be used synergistically to support endothelial health, nitric oxide production, microbial balance, and joint…

People in this episode

Host: Dr. Kara Fitzgerald

Guest: Kiran Krishnan

Topics covered

• vascular aging
• endothelial dysfunction
• metabolic changes
• perimenopause
• gut microbiome
• cardiovascular health

Keywords

• cardiovascular health
• estrogen decline
• endothelial glycocalyx
• nitric oxide signaling
• gut microbiome
• metabolic resilience
• perimenopause

Mentioned in this episode

Products: Arterosil, Vascanox, Cartigenix

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