About this episode

This episode discusses how impaired immune function contributes to aging and explores potential therapeutic interventions.

🧬 What if aging is driven not only by accumulated damage, but by the failure of our immune system to take out the cellular "trash"? This fascinating Science study identifies impaired clearance of senescent neutrophils by tissue-resident macrophages as a reversible driver of multiorgan aging. Blocking the EP2 receptor restored immune housekeeping and improved cognition, frailty, muscle, cardiac, and liver function in aged mice. An elegant mechanistic study that opens exciting possibilities for future geroscience therapeutics. 🎙️ #Aging #Immunology #Geroscience #MedicalEducation #MedicalPodcasts

People in this episode

Host: Dr RR Baliga

Topics covered

• aging
• immunology
• geroscience
• medical education
• healthy aging

Keywords

• aging
• immune system
• senescent cells
• macrophages
• geroscience
• cognition
• therapeutics

Mentioned in this episode

Organizations: Science

Books & works: Fountain of Youth, EP2

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