About this episode

The episode discusses a clinical trial showing the efficacy of semaglutide in treating alcohol use disorder and its implications for addiction medicine.

A fascinating Lancet RCT shows once-weekly semaglutide may redefine alcohol use disorder treatment. 🎯 In 108 adults with AUD and obesity, semaglutide reduced heavy drinking days by –13.7 percentage points vs placebo (p=0.0015) and improved craving, consumption, and biomarkers. 📉 With an NNT of ~4.3 and a manageable safety profile, GLP-1 therapy signals a shift from abstinence to precision harm reduction . 💡 Efficacy. Safety. Meaningful impact. Is this the beginning of a new era in addiction medicine? 🧠💉

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