Sermorelin 101: How This Peptide Stimulates Natural Growth Hormone | The Peptides Conversation
About this episode
Dr. Susan Hardwick-Smith reviews sermorelin, explaining its role in stimulating natural growth hormone and its physiological implications.
In this video, I review sermorelin, a growth hormone–elevating peptide, and explain where it fits physiologically within the growth hormone axis. I begin by defining what peptides are and what is meant by a growth hormone–elevating peptide, then clarify what sermorelin is — and what it is not. HOW SERMORELIN WORKS, Sermorelin is a synthetic analog of growth hormone–releasing hormone (GHRH). It acts at the level of the pituitary gland to stimulate endogenous, pulsatile growth hormone secretion, rather than providing exogenous growth hormone. I discuss the downstream effects of growth hormone signaling, including its role in: ❇️ sleep regulation ❇️ bone metabolism ❇️ muscle and body composition ❇️ skin integrity ❇️ cognitive function I also address a common question: Why don’t we simply administer growth hormone? This section reviews the physiologic risks of bypassing hypothalamic–pituitary regulation, including suppression of natural hormone signaling and elevations in IGF-1. Finally, I conclude with an overview of clinical considerations surrounding administration, including dosing, timing, and cost. My goal is to help you understand where sermorelin fits within normal hormone…
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