745: Why You’re Wired, Tired, and Awake at 3AM (And What to Do About It) with Dr. Scott Sherr

745: Why You’re Wired, Tired, and Awake at 3AM (And What to Do About It) with Dr. Scott Sherr

May 12, 2026 · 1h 11m

About this episode

Dr. Mariza and Dr. Scott Sherr discuss the factors contributing to sleep struggles and anxiety in women during perimenopause and offer practical solutions.

Why are so many women waking up exhausted… but unable to shut their brain off?” In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife. Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood. They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again. If you’ve been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle. Dr. Scott Sherr Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep…

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