Your Best Shot: Holistic Approach to GLP-1
From Evolution of Medicine Podcast by Functional Forum
February 23, 2026 · 36 min · Season 2 · Episode 17
About this episode
The episode discusses a holistic approach to GLP-1 agonists and emphasizes a shift from weight loss to weight health.
In this episode of The Evolution of Medicine, host James Maskell interviews registered dietitian Ashley Koff about her new book Your Best Shot. The conversation explores the seismic impact of GLP-1 agonists like Ozempic and Wegovy—and how functional medicine can pivot from a "weight loss" mindset to a "weight health" approach. Koff reframes these medications not as magic bullets, but as biosimilar hormone replacement tools that "switch on" receptor sites—without repairing the underlying ecosystem. She outlines a five-part Weight Health Hormone assessment and introduces a Physician–Dietitian–Health Coach triad to ensure sustainable outcomes. The episode challenges practitioners to stay "agnostic about the agonist" and instead focus on metabolic repair, patient education, and structured team-based care. About the Guest: Ashley Koff, RD is a registered dietitian and functional nutrition expert focused on metabolic health, personalized nutrition, and hormone signaling. She is the author of Your Best Shot and advocates for a "Weight Health" approach that integrates assessment, repair, and team-based implementation. Ashley Koff, RD Website…
People in this episode
Host: James Maskell
Guest: Ashley Koff
Topics covered
- GLP-1 agonists
- functional medicine
- weight health
- metabolic repair
- team-based care
Keywords
- GLP-1
- Ozempic
- Wegovy
- functional medicine
- metabolic health
- hormone replacement
- weight health
- nutrition
Mentioned in this episode
Organizations: The Evolution of Medicine, Physician–Dietitian–Health Coach triad
Products: Ozempic, Wegovy
Books & works: Your Best Shot
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