Can Aging Be Reversed by Science?

About this episode

This episode explores the potential for reversing or slowing aging through scientific advancements in cellular reprogramming and epigenetics.

Can aging be reversed, or slowed in a meaningful way. This episode covers cellular reprogramming, OSK, Yamanaka factors, epigenetic aging, and the key studies behind the claims. You will hear what the mouse data showed, what chemical reprogramming achieved in human cells, and where the science still has limits. References: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors The original 2006 iPS paper. It introduced the four factors Oct3/4, Sox2, c-Myc, and Klf4. Source Reprogramming to recover youthful epigenetic information and restore vision This Nature paper reported that OSK restored youthful DNA methylation patterns, promoted axon regeneration, and reversed vision loss in mouse models. Source Full text via PubMed Central for the OSK vision paper Useful if you want the full paper without a paywall. Source Chemically induced reprogramming to reverse cellular aging This paper reported six chemical cocktails that restored a youthful transcript profile in human cells in under a week, without changing cell identity. Source Full text for the chemical reprogramming paper Direct publisher link to the full study. Source Loss of…

People in this episode

Host: Pavlos Giorkas

Topics covered

• aging
• cellular reprogramming
• epigenetics
• Yamanaka factors
• scientific studies

Keywords

• aging
• cellular reprogramming
• Yamanaka factors
• epigenetic aging
• scientific studies

Mentioned in this episode

Organizations: ClinicalTrials.gov

Books & works: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Reprogramming to recover youthful epigenetic information and restore vision, Chemically induced reprogramming to reverse cellular aging, Loss of epigenetic information as a cause of mammalian aging

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