Can Alzheimer’s Be Prevented? The Brain Science Everyone Should Know with Dr. David Perlmutter

Can Alzheimer’s Be Prevented? The Brain Science Everyone Should Know with Dr. David Perlmutter

August 27, 2026 · 1h 2m · Episode 201

About this episode

Dr. David Perlmutter discusses the early signs of Alzheimer's and the importance of prevention through lifestyle choices.

What if Alzheimer’s doesn’t begin when you start forgetting names or struggling with memory but decades earlier, when subtle changes are happening in your metabolism, inflammation, and brain?   With Alzheimer’s in my own family, this conversation with Dr. David Perlmutter felt especially personal. Dr. Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and one of the leading voices challenging how we think about brain health and cognitive decline. His new book, Brain Defenders, explores emerging research around microglia — the immune cells of the brain — and why they may hold an important key to protecting our brains as we age.   We dive into why Dr. Perlmutter believes we need to start thinking about Alzheimer’s prevention in our 30s and 40s, the surprising connection between metabolic health and the brain, and how our everyday choices may influence whether our brain’s immune cells protect us or work against us. We also get into the role of ultra-processed foods, blood sugar and insulin, the gut microbiome, environmental toxins, sleep, inflammation, mitochondria, vitamin D, and some of the biomarkers Dr. Perlmutter believes are…

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