February 10, 2026: Amyloidosis in Focus: Diagnosis Delays, Early Treatment, and What Clinicians Must Know | JACC This Week
About this episode
This episode discusses the challenges and advancements in diagnosing and treating cardiac amyloidosis, emphasizing the importance of timely intervention and equity in care.
In this episode of JACC This Week, Dr. Harlan M. Krumholz and Dr. Carolyn S.P. Lam discuss a dedicated issue of JACC focused on cardiac amyloidosis—one of the fastest-evolving areas in cardiovascular medicine. They explore new evidence highlighting significant delays in diagnosing ATTR cardiomyopathy, the early divergence of mortality benefit with timely treatment, and why time to diagnosis is no longer a neutral factor. The conversation also examines secondary analyses from major clinical trials, practical guidance for amyloidosis evaluation and management, and Dr. Krumholz's Editor's Page on "computable diagnosis" as a moral imperative. This episode places emerging science in clinical context, emphasizing urgency, equity, and how clinicians should be thinking differently about diagnosis, staging, and access to therapy in amyloid heart disease. Read Full issue here: https://www.jacc.org/toc/jacc/87/5 Keywords: cardiac amyloidosis, amyloid heart disease, ATTR cardiomyopathy, computable diagnosis
People in this episode
Host: Dr. Harlan M. Krumholz
Guest: Dr. Carolyn S.P. Lam
Topics covered
- cardiac amyloidosis
- ATTR cardiomyopathy
- diagnosis delays
- early treatment
- clinical guidance
- mortality benefit
- equity in healthcare
Keywords
- cardiac amyloidosis
- amyloid heart disease
- ATTR cardiomyopathy
- diagnosis delays
- early treatment
- clinical trials
- computable diagnosis
Mentioned in this episode
Organizations: American College of Cardiology
Books & works: JACC, computable diagnosis
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