#297 - Does Most Chronic Disease Come Down to “Energy Flow?” | Greg Mushen and Josh Clemente

#297 - Does Most Chronic Disease Come Down to “Energy Flow?” | Greg Mushen and Josh Clemente

From LEVELS – A Whole New Level by Levels

April 23, 2026 · 1h 35m

About this episode

The episode discusses the importance of energy flow in metabolic health and chronic disease resistance with insights from Greg Mushen's Theory of Flux.

Metabolic health is often simplified to a matter of blood sugar, but at its root, it is a complex system of energy substrate signaling. While many view chronic disease as an inevitable part of aging, a systems-thinking approach reveals that maintaining high "flux"—the capacity to efficiently move and clear energy through the body—is the primary lever for longevity. Without the stimulus of regular movement, even the most optimized diet can fail to prevent the accumulation of metabolic waste that leads to insulin resistance and heart disease. In this episode, we sit down with Greg Mushen, a technologist who turned his engineering mind toward his own biology after conventional medicine failed to address his chronic health issues. Mushen breaks down his "Theory of Flux" and why he believes the key to disease resistance lies in meeting our body's "clearance burden". From studying the activity levels of hunter-gatherer populations to debunking myths about walking and V2 max, Mushen provides a data-driven framework for optimizing health through the lens of evolutionary biology and systems engineering. Sign Up to Get Your Free Ultimate Guide to Glucose…

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