#300 - Who Should Take GLP-1s? The Science of Obesity, Appetite & Weight Loss | Dr. Robert Kushner & Mike Haney

#300 - Who Should Take GLP-1s? The Science of Obesity, Appetite & Weight Loss | Dr. Robert Kushner & Mike Haney

June 4, 2026 · 1h 14m

About this episode

Dr. Robert Kushner discusses the science behind GLP-1 drugs and their implications for obesity treatment with host Mike Haney.

What are GLP-1 drugs actually doing in the body, who are they for, and why might some people want to think twice before treating them like a six-month shortcut? For years, obesity treatment focused largely on behavior: eat less, move more, stay motivated. Yet many people lost weight only to regain it. According to obesity medicine pioneer Dr. Robert Kushner, that wasn’t a failure of willpower. It was a failure to fully understand the biology driving weight regulation. In this episode of A Whole New Level, Mike Haney sits down with Kushner, one of the leading figures in obesity medicine and a lead investigator on the landmark STEP trials, to discuss how GLP-1 medications are changing the field. He explains why these drugs may be the first treatments capable of helping patients “fight biology with biology,” why appetite regulation appears to work differently in different people, and why many patients describe a dramatic reduction in food noise after starting treatment. But this conversation goes beyond how the drugs work. Kushner also addresses one of the biggest questions facing obesity medicine today: who should actually take these medications? He explains why obesity specialists…

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