#478 — The Psychedelic Mind

#478 — The Psychedelic Mind

From Making Sense with Sam Harris by Sam Harris

May 29, 2026 · 30 min

About this episode

Sam Harris speaks with Robin Carhart-Harris about psychedelic research and its therapeutic potential.

Sam Harris speaks with Robin Carhart-Harris about psychedelic research and its therapeutic potential. They discuss the current state of the field, the FDA denial of MDMA-assisted therapy for PTSD, the critical role of set and setting, risks for vulnerable populations, the REBUS model of how psychedelics work on the brain, the default mode network and ego dissolution, microdosing, the neuroscience of consciousness, DMT entities, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe .

People in this episode

Host: Sam Harris

Guest: Robin Carhart-Harris

Topics covered

  • psychedelic research
  • therapeutic potential
  • PTSD treatment
  • set and setting
  • neuroscience
  • consciousness
  • ego dissolution

Keywords

  • psychedelics
  • therapy
  • MDMA
  • PTSD
  • microdosing
  • consciousness
  • neuroscience

Mentioned in this episode

Organizations: FDA

Books & works: MDMA-assisted therapy, REBUS model, default mode network, ego dissolution, microdosing, neuroscience of consciousness, DMT entities

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