Rethinking Parkinson’s: The Somato-Cognitive Action Network (SCAN) hypothesis
About this episode
Dr. Michele Matarazzo interviews Prof. Hesheng Liu about a new hypothesis regarding Parkinson's disease as a somato-cognitive action network disorder.
Dr. Michele Matarazzo interviews Prof. Hesheng Liu about his recent Nature paper proposing a major conceptual shift: Parkinson’s disease as a somato-cognitive action network (SCAN) disorder. Together they discuss how a large multimodal dataset suggests a characteristic pattern of hyperconnectivity between SCAN cortical areas and subcortical nuclei in Parkinson’s disease, how this signature changes with effective therapies, and why personalized SCAN targeting may help refine non-invasive stimulation and circuit-guided interventions. The conversation explores implications for biomarkers, patient-specific targeting, and key unanswered questions that will shape the next generation of studies. Read the article.
People in this episode
Host: Michele Matarazzo
Guest: Prof Hesheng Liu
Topics covered
- Parkinson's disease
- somato-cognitive action network
- hyperconnectivity
- personalized targeting
- biomarkers
Keywords
- Nature paper
- multimodal dataset
- effective therapies
- non-invasive stimulation
- circuit-guided interventions
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