Gary Schroth on Connecting Cellular Behavior to the Transcriptome

About this episode

Gary Schroth discusses the integration of transcriptomics and live-cell imaging to better understand cellular behavior.

For decades, biology has been driven by the powerful notion that if we could sequence enough genomes, transcriptomes, epigenomes, then we could finally explain the cell. On today’s show, Gary Schroth, the Chief Scientific Officer at Cellanome, argues that something essential was still missing. Schroth spent nearly two decades at Illumina helping build the sequencing revolution. He has now joined Cellanome to pursue an expanded vision of biology that connects transcriptomics with live-cell imaging. Our conversation centers around two newly released preprints describing the company’s platform and its application to CRISPR screening, where imaging and transcriptomic data are explicitly linked in the very same cells. “What we show in a few examples in both papers,” Schroth explains, “is that it’s the combination of transcriptome information and imaging information that really gives us the complete story of what that cell is doing.” That idea—linking what researchers literally see under the microscope with the molecular state of the exact same cell—emerges as the core concept of the interview. Rather than treating imaging and transcriptomics as separate measurements, Cellanome brings…

People in this episode

Host: Theral Timpson

Guest: Gary Schroth

Topics covered

• cellular behavior
• transcriptome
• live-cell imaging
• CRISPR screening
• biology

Keywords

• transcriptomics
• live-cell imaging
• CRISPR
• sequencing
• biology
• Cellanome
• genomes

Mentioned in this episode

Organizations: Cellanome, Illumina

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