Glucose: The Brain's Panic Button

Glucose: The Brain's Panic Button

June 19, 2026 · 3 min

About this episode

This episode discusses how a drop in plasma glucose triggers hormonal responses to restore glucose levels in the brain.

The brain's panic button is a precipitous drop in plasma glucose. Its response through the hypothalamus initiates the release of glucagon, epinephrine and cortisol from the pancreas and adrenal glands, respectively. The outcome of these hormones is to instruct the liver through their respective receptors to increase its output of glucose, thus restoring it to its normal levels.

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