NNMT, Cancer & Fat Loss: The Hidden Link You Need to Understand

NNMT, Cancer & Fat Loss: The Hidden Link You Need to Understand

March 25, 2026 · 31 min · Episode 125

About this episode

The episode explores the relationship between NNMT, cancer risk, and fat loss, focusing on the implications of 5-Amino-1MQ.

NNMT, Cancer Risk & 5-Amino-1MQ – Where Science Ends and Assumptions Begin Alright… this one is interesting. Because I talk a lot about 5-Amino-1MQ—mainly in the context of fat loss, metabolic health, and keeping weight off long term. But recently, I was in a conversation with a doctor…and he told me he personally takes it because his mother died from a glioblastoma. And his reasoning? 👉 It inhibits NNMT👉 NNMT is involved in certain cancers👉 So… maybe there’s something there Now before we go any further— I am NOT saying 5-Amino prevents or treats cancer.And neither was he. What he was doing…was taking a known biological pathway and making an informed assumption. And honestly? It’s a fascinating one. 🧬 What is NNMT (and why does it matter)? NNMT (Nicotinamide N-Methyltransferase) is an enzyme involved in how your body manages: Energy production NAD+ levels Metabolic function Aging processes When NNMT is elevated, it’s associated with: Fat storage Insulin resistance Slower metabolic function Lower NAD+ availability 👉 This is why it shows up so strongly in midlife weight gain And it’s also why I talk so much about 5-Amino-1MQ—because it inhibits NNMT, which can shift the…

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