HOT TOPICS: Prophylactic Antiseizure Medication in Lobar Intracerebral Hemorrhage

HOT TOPICS: Prophylactic Antiseizure Medication in Lobar Intracerebral Hemorrhage

From Neurocritical Care Society Podcast by Neurocritical Care Society

April 8, 2026 · 20 min

About this episode

The episode discusses the use of prophylactic antiseizure medication in patients with lobar intracerebral hemorrhage, exploring current guidelines and evidence.

In this episode of the NCS Podcast Hot Topics series, host Richard Choi, DO, FNCS, is joined by Wendy Ziai, MD, professor of neurology and critical care medicine at Johns Hopkins University, to discuss the article " Prophylactic Anti-Seizure Medication in Patients with Lobar Intracerebral Hemorrhage " , recently published in Neurocritical Care . Their conversation explores the ongoing debate surrounding prophylactic antiseizure medication use in patients with lobar intracerebral hemorrhage. They review current guideline recommendations, highlight limitations in the existing evidence and consider the challenge of balancing seizure prevention with the risk of adverse effects. Dr. Ziai reviews key findings from prior trials as well as the featured study, which demonstrated lower rates of early seizures among patients who received prophylaxis. She also addresses questions related to patient selection, nonconvulsive status epilepticus and long-term cognitive outcomes. The discussion further considers the role of continuous EEG monitoring in the first 48 hours and how future study designs may help clarify which patients, if any, are most likely to benefit. The views expressed on the…

People in this episode

Host: Richard Choi, DO, FNCS

Guests: Wendy Ziai, MD, Wendy Ziai

Topics covered

  • prophylactic antiseizure medication
  • lobar intracerebral hemorrhage
  • seizure prevention
  • adverse effects
  • continuous EEG monitoring
  • cognitive outcomes

Keywords

  • antiseizure medication
  • intracerebral hemorrhage
  • seizures
  • EEG monitoring
  • cognitive outcomes
  • clinical guidelines
  • neurology

Mentioned in this episode

Organizations: Johns Hopkins University, Neurocritical Care, Neurocritical Care Society

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