Redefining Bioconjugation and the Future of ADCs with Dr. Abbas Sahili of Singzyme

Redefining Bioconjugation and the Future of ADCs with Dr. Abbas Sahili of Singzyme

May 16, 2025 · 36 min · Season 2 · Episode 9

About this episode

Dr. Abbas Sahili discusses his journey from academia to biotech leadership and the innovations at Singzyme in bioconjugation technologies.

Dr. Abbas Sahili is the CTO of Singzyme, a biotechnology company pioneering next-generation bioconjugation technologies. With a strong background in biochemistry and structural biology, Abbas brings deep scientific expertise and entrepreneurial vision to the field of precision medicine. His transition from academia to biotech leadership is marked by a commitment to developing antibody-drug conjugates (ADCs) that are more efficient, effective, and accessible. Under his leadership, Singzyme has developed a proprietary platform leveraging Peptide Asparaginyl Ligase (PAL) technology, setting a new standard in ADC manufacturing and performance. In this episode, Dr. Abbas Sahili walks us through his unique journey from academic research in structural biology to founding Singzyme, a cutting-edge biotech startup. He shares the motivations that led him to pivot from lab-based research to real-world therapeutic development and the founding story of Singzyme. Dr. Sahili breaks down complex concepts like antibody-drug conjugates and bioconjugation in a way that’s easy to understand. He discusses Singzyme’s PAL technology, a novel enzymatic platform that offers significant advantages over…

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