
Tackling “the Biggest Question That Everyone Is Asking” in Breast Cancer Care
From Oncology News Central Peer-Spectives by Oncololgy News Central
April 2, 2026 · 14 min · Episode 25
About this episode
The episode discusses the current approaches to treating ESR1-mutated advanced breast cancer and the potential use of SERDs in various patient scenarios.
How are oncologists currently approaching the care of patients with ESR1-mutated advanced breast cancer in practice? Erin Frances Cobain, MD, associate professor at the University of Michigan Rogel Cancer Center in Ann Arbor, speaks with Wassim Mchayleh, MD, MBA, the clinical program director of the breast cancer program at AdventHealth Cancer Institute and associate professor of medicine at the University of Central Florida in Orlando, about how to best use oral selective estrogen receptor degraders. “And the big question is ‘Can we use SERDs in combination, or are SERDs effective in patients without an ESR1 mutation?’ Can we go outside the current approved guidelines? And I think that’s the biggest question that everyone is asking today,” notes Dr. Mchayleh.
People in this episode
Host: Erin Frances Cobain, MD
Guest: Wassim Mchayleh, MD, MBA
Topics covered
- breast cancer
- ESR1 mutation
- oncology
- SERDs
- advanced breast cancer
- patient care
Keywords
- breast cancer care
- ESR1 mutation
- oral selective estrogen receptor degraders
- oncologists
- advanced breast cancer
Mentioned in this episode
Organizations: University of Michigan Rogel Cancer Center, AdventHealth Cancer Institute, University of Central Florida
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