New Targeted Therapies Make Breast Cancer Treatment Decisions “a Bit of a Moving Target”

About this episode

Dr. Hope S. Rugo discusses the evolving landscape of breast cancer treatment and decision-making in light of new therapies.

“In breast cancer now, all of our treatment for hormone receptor–positive metastaticdisease is a bit of a moving target because of new therapies that are available,”explains Hope S. Rugo, MD, division chief of breast medical oncology and the Women’sCancers Program director at the City of Hope Comprehensive Cancer Center in Duarte,California. She discusses the “ever-changing” landscape involving the PI3kinase/AKT/mTOR pathway with Robert A. Figlin, MD, the Steven Spielberg FamilyChair in Hematology-Oncology at Cedars-Sinai Cancer in Los Angeles. Dr. Rugo detailskey considerations that she uses for decision making in practice. “And I think we justwant to be cautious about toxicity for these patients and really know that we’rebenefiting them, rather than using up treatments,” she explains.

People in this episode

Host: Robert A. Figlin, MD

Guests: Hope S. Rugo, MD, Hope S. Rugo

Topics covered

• breast cancer
• targeted therapies
• hormone receptor-positive
• treatment decisions
• PI3kinase/AKT/mTOR pathway
• oncology

Keywords

• breast cancer
• targeted therapies
• hormone receptor-positive
• metastatic disease
• treatment decisions
• oncology
• toxicity
• PI3kinase
• AKT
• mTOR

Mentioned in this episode

Organizations: City of Hope Comprehensive Cancer Center, Cedars-Sinai Cancer

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