
161: We Got ROSC... Now What? Evidence Based Post Resuscitation Care
From Rapid Response RN by Sarah Lorenzini
April 24, 2026 · 31 min
About this episode
This episode discusses the critical steps and considerations in post-resuscitation care following the return of spontaneous circulation (ROSC).
Getting ROSC is not always the win we sometimes think it is. It's what we're looking for the entire resuscitation, but the real challenge begins once we get it… and what we do in the next few hours has a major impact on patient outcomes. In this episode, Sarah shares a real rapid response case to walk through the physiology, decision-making, and advocacy of post-arrest care. The 2025 AHA post resuscitation guidelines have brought important shifts to post-ROSC management, from how aggressively to oxygenate to when it's safe to prognosticate. Don't miss the full breakdown! Topics discussed in this episode: Oxygenation and ventilation: how to avoid hyperoxia and hypoxia Perfusion, pressors, and the limits of MAP Temperature management guidelines Sedation, analgesia, and the paralyzed-but-awake patient Diagnostics: timing, priorities, and what to rule out How to use neuroprognostication the right way How to talk to families without giving false hope Nursing priorities and how to advocate for your patients Check out the new Post Resuscitation Guidelines: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001375 Listen to episode 73 — Resuscitate Before You Intubate: How to NOT KILL…
People in this episode
Host: Sarah Lorenzini
Topics covered
- post-resuscitation care
- patient outcomes
- oxygenation and ventilation
- temperature management
- neuroprognostication
- nursing advocacy
Keywords
- ROSC
- post-resuscitation
- patient care
- AHA guidelines
- oxygenation
- ventilation
- neuroprognostication
- nursing priorities
Mentioned in this episode
Organizations: AHA
Books & works: Post Resuscitation Guidelines, Resuscitate Before You Intubate: How to NOT KILL YOUR PATIENT When You Intubate
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