Episode 101: Acute Liver Failure: Differentials, Deterioration and Decisive Action

Episode 101: Acute Liver Failure: Differentials, Deterioration and Decisive Action

February 25, 2026 · 42 min

About this episode

This episode explores the critical aspects of acute liver failure through a detailed case study.

In this episode of the RCP Medicine Podcast, transplant hepatologist Dr Mhairi Donnelly joins gastroenterology trainee Dr Jennifer Tham to explore the high‑stakes world of acute liver failure. Through a detailed case of a young woman presenting with severe transaminitis and paracetamol toxicity, Mhairi and Jennifer guide listeners through the crucial steps in recognising acute liver injury, identifying early markers of deterioration, and escalating care at the right time. The discussion cover...

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Host: Dr Jennifer Tham

Guest: Dr Mhairi Donnelly

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Organizations: Royal College of Physicians

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