Cracking the Code of Obstruction: Unmet Needs in oHCM

Cracking the Code of Obstruction: Unmet Needs in oHCM

From ReachMD CME by ReachMD

March 26, 2026 · 5 min

About this episode

This episode discusses the management of obstructive hypertrophic cardiomyopathy and the need for precision-based therapies.

CME credits: 1.00 Valid until: 19-05-2027 Claim your CME credit at https://reachmd.com/programs/cme/cracking-the-code-of-obstruction-unmet-needs-in-ohcm/54837/ This activity examines the evolving management of obstructive hypertrophic cardiomyopathy (oHCM), from persistent unmet needs to precision-based therapy with cardiac myosin inhibitors. Faculty review ongoing symptom burden and functional limitations despite guideline-directed first-line therapy with beta-blockers and analyze mechanistic, pharmacokinetic, and pharmacodynamic differences among available agents, including their effects on peak VO₂, left ventricular outflow tract gradients, and patient-reported outcomes. Through expert discussion and case-based application, the activity highlights practical considerations for treatment selection, individualized dosing and titration, safety monitoring, and treatment transitions to support evidence-based strategies that optimize hemodynamics and improve quality of life in patients with oHCM.

Topics covered

  • obstructive hypertrophic cardiomyopathy
  • management strategies
  • precision-based therapy
  • treatment selection
  • patient-reported outcomes

Keywords

  • oHCM
  • beta-blockers
  • hemodynamics
  • quality of life
  • treatment transitions
  • symptom burden
  • functional limitations

Mentioned in this episode

Organizations: ReachMD, obstructive hypertrophic cardiomyopathy

Products: cardiac myosin inhibitors

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