About this episode

This episode discusses the future of xenotransplantation and its potential to address the global organ shortage.

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Diane C. McLaughlin, DNP, AGACNP-BC, CCRN, FCCM, speaks with Muhammad Mansoor Mohiuddin, MD, MBBS, DSc (Hon), FAST, director of the Cardiac Xenotransplantation Program at the University of Maryland School of Medicine, about his Thought Leader presentation at the 2025 Critical Care Congress, The Remarkable Potential of Xenotransplantation, and his groundbreaking work on that subject. Dr. Mohiuddin discusses the need to address the global shortage of donated organs and the use of genetically modified pig organs as a viable solution. He explains the science behind xenotransplantation, including the use of CRISPR-Cas9 gene editing technology to delete immunogenic pig genes and insert human-compatible genes. The conversation explores the unique immunologic challenges of xenotransplantation, particularly antibody-mediated rejection and the need for tailored immunosuppression protocols. Ethical considerations include religious perspectives and public opinion. Dr. Mohiuddin emphasizes the importance of continued research funding and collaboration with industry partners to advance clinical trials and refine…

People in this episode

Host: Diane C. McLaughlin

Guest: Muhammad Mansoor Mohiuddin

Topics covered

• xenotransplantation
• organ donation
• gene editing
• immunology
• ethical considerations
• medical research

Keywords

• xenotransplantation
• organ shortage
• CRISPR-Cas9
• immunogenic genes
• clinical trials
• genetic modifications
• immunosuppression
• ethical considerations

Mentioned in this episode

Organizations: University of Maryland School of Medicine, Society of Critical Care Medicine

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