A Mold with a Grudge

A Mold with a Grudge

From Sidedoor by Smithsonian Institution

December 10, 2025 · 39 min · Season 12 · Episode 2

About this episode

This episode explores the story of how penicillin, the world's first antibiotic, was discovered through a collaboration during wartime.

It started with a messy lab and a mysterious mold. But turning “mold juice” into the world’s first antibiotic would take a sick policeman, a market cantaloupe, and an extraordinary wartime collaboration between scientists, governments, and industry. This is the story of how penicillin changed the world. Guests: Kevin Brown , Trust Archivist to Imperial College Healthcare NHS Trust and curator of the Alexander Fleming Laboratory Museum at St. Mary’s Hospital; author of Penicillin Man: Alexander Fleming and the Antibiotic Revolution Diane Wendt , curator in the Division of Medicine and Science at the Smithsonian's National Museum of American History

People in this episode

Guests: Kevin Brown, Diane Wendt

Topics covered

  • antibiotics
  • history of medicine
  • scientific collaboration
  • World War II
  • Alexander Fleming
  • penicillin
  • mold

Keywords

  • penicillin
  • antibiotic
  • Alexander Fleming
  • mold
  • scientific discovery
  • World War II
  • medicine
  • history

Mentioned in this episode

Organizations: Imperial College Healthcare NHS Trust, Alexander Fleming Laboratory Museum, Smithsonian's National Museum of American History

Books & works: Penicillin Man: Alexander Fleming and the Antibiotic Revolution

Places: St. Mary’s Hospital

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