#613: Supplement Safety & Medication Interactions – Giulia Guerrini, MPharm

#613: Supplement Safety & Medication Interactions – Giulia Guerrini, MPharm

July 14, 2026 · 57 min

About this episode

Giulia Guerrini discusses the complexities of supplement safety and medication interactions.

Supplement safety is often discussed in very general terms, but in practice the risks depend heavily on the individual. A supplement that is reasonable for one person may be inappropriate for another based on their medications, health conditions, dose, formulation, or the other products they are already using. This becomes especially important when supplements interact with medications or underlying medical conditions. Some interactions can change how a drug is absorbed, metabolised, transported, or cleared from the body. Others can amplify or oppose the drug's clinical effect, such as increasing sedation, lowering blood pressure or blood glucose, or affecting bleeding risk. In this episode, Giulia Guerrini, a GPhC-registered pharmacist and researcher at Examine, talks about how clinicians and practitioners can think more systematically about supplement safety, side effects, contraindications, and drug–supplement interactions. Timestamps: [02:39] Interview start [05:21] Why context matters [06:38] Timing and formulation [12:58] Rating interaction risk [22:39] Berberine benefits and interactions [27:33] Adaptogens quality concerns [30:15] Melatonin safety questions [36:30]…

More episodes of Sigma Nutrition Radio

Explore listener stats, chart rankings, contacts and more on the Sigma Nutrition Radio podcast page.