About this episode

The episode discusses the wired-but-tired phenomenon in midlife women, exploring its causes and solutions with Dr. Scott Sherr.

Do you feel exhausted but can't seem to wind down? That wired-but-tired feeling so many women experience in midlife has a name, and a cause most doctors never address. In this episode of The Art of Living Well Podcast®, Marnie and Stephanie are joined by Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization, to explore the connection between chronic stress, hormone changes, and mitochondrial dysfunction. Dr. Scott introduces the concept of the "sympathetic spiral of doom" — the cycle of stress, poor sleep, and cellular energy breakdown that keeps so many women stuck, and shares practical, science-backed ways to break it. The conversation covers methylene blue (what it is, how it works, and who should use it), GABA and nervous system support, and hyperbaric oxygen therapy. Dr. Scott also explains why only 6% of US adults have optimally functioning mitochondria, and what the other 94% can do about it. Key Takeaways: Chronic stress and hormone fluctuations directly impair mitochondrial function Estrogen is a critical mitochondrial optimizer, losing it in perimenopause has real cellular consequences Only 6% of US adults are metabolically…

People in this episode

Hosts: Marnie Dachis Marmet, Stephanie May Potter

Guest: Dr. Scott Sherr

Topics covered

• midlife health
• mitochondrial dysfunction
• chronic stress
• hormone changes
• methylene blue
• GABA
• hyperbaric oxygen therapy

Mentioned in this episode

Organizations: The Art of Living Well Podcast

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