Network Segmentation to Prevent Ransomware: What the UCSF Attack Taught Us

Network Segmentation to Prevent Ransomware: What the UCSF Attack Taught Us

From The Backup Wrap-Up by W. Curtis Preston (Mr. Backup)

May 4, 2026 · 47 min

About this episode

This episode discusses the importance of network segmentation in preventing ransomware, using the UCSF attack as a case study.

Network segmentation to prevent ransomware isn't just a nice-to-have — the UCSF ransomware attack proves it's what separates a contained incident from a catastrophe. UCSF got hit. Their segmented network kept the damage from spreading across their entire operation. That's the difference we're talking about in this episode. Dr. Mike Saylor — my co-author on Learning Ransomware Response and Recovery — joins me and Prasanna to break down exactly how network segmentation works, why it matters for ransomware defense, and how to start doing it without breaking everything in the process. (Not that I've ever done that. Much.) We cover what segmentation actually is, how VLANs make it manageable, the "need to talk" principle, and where microsegmentation fits in — and when it becomes overkill. We also get into the complexity trap: more rules and more layers don't automatically mean more protection. Sometimes they mean nobody can troubleshoot anything when the house is on fire. If you're an IT admin trying to make the case for better network architecture, or you just want to understand what would actually stop ransomware from ripping through your environment, this is the episode. Chapters…

People in this episode

Host: W. Curtis Preston

Guest: Dr. Mike Saylor

Topics covered

  • network segmentation
  • ransomware prevention
  • UCSF ransomware attack
  • VLANs
  • microsegmentation
  • IT security

Keywords

  • network segmentation
  • ransomware
  • UCSF
  • VLANs
  • microsegmentation
  • IT security
  • complexity trap

Mentioned in this episode

Organizations: UCSF

Books & works: Learning Ransomware Response and Recovery

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