Reimagining Bioreactors to Solve Manufacturing Bottlenecks with Brian Heligman

Reimagining Bioreactors to Solve Manufacturing Bottlenecks with Brian Heligman

December 10, 2025 · 60 min

About this episode

The episode discusses how changing bioreactor constraints can address manufacturing bottlenecks in biomanufacturing with insights from Brian Heligman.

Biomanufacturing doesn’t fail for lack of clever biology; it stalls at the factory gate. We sit down with Biosphere CEO Brian Heligman to unpack how a materials scientist’s journey through batteries and perovskites led to a bold thesis for the bioeconomy: change the constraints of the bioreactor and you change everything downstream. Instead of miles of steam lines and fragile commissioning, Biosphere is betting on UV-sterilized stainless systems, modern automation, and a full-stack approach t...

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Guest: Brian Heligman

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Organizations: Biosphere, Homeworld Collective

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