#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing

#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing

From The Curbsiders Internal Medicine Podcast by The Curbsiders Internal Medicine Podcast

March 16, 2026 · 1h 6m

About this episode

The episode reviews recent articles on weight regain after weight loss medications, GLP-1/GIP comparisons, valacyclovir for Alzheimer’s, and strategies to encourage deprescribing.

Join us as we review and appraise recent practice-changing articles. In this episode, we cover the latest in GLP-1s and GIP agonists for CVD, Type 2 Diabetes, and Obesity, valacyclovir to treat Alzheimer’s, weight regain patterns after medication-induced weight loss, and a deep dive into the data behind deprescribing – and behavioral science to increase deprescribing behavior. Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams ( @PaulNWilliamz ), Alex Chaitoff ( @alexchaitoff ), Nora Taranto ( @norataranto ), & Matt Watto (@doctorwatto) . Claim CME for this episode at curbsiders.vcuhealth.org ! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Credits Written and Hosted by: Nora Taranto MD, MSCE; Alexander Chaitoff MD, MPH; Paul Williams, MD, FACP,, & Matthew Watto MD, FACP Cover Art: Nora Taranto MD, MSCE Reviewer: Sai S Achi MD, MBA, FACP Technical Production: Pod Paste Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Show Segments Intro, disclaimer GLP-1 + GIPs vs GLP-1s for patients with T2DM and Obesity – SURPASS-CVOT Weight Regain after Weight loss VALAD – Valacyclovir in patients with…

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